Abstract not available.

is not a generalised situation. Secondary prevention of. "Genomic Strategies in Cancer Prevention: A Pancreatic Cancer Perspective." Computer Engineering, vol. 15, no. 5, pp. 1–7, 2026.

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Ammar Hisham M, Khalid Nada A. "Effects of Self-Cure Acrylic Methyl Methacrylate Monomer on Hsp90 Expression in Rat Lungs." Computer Engineering, vol. 15, no. 5, pp. 8–10, 2026.

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Developmental origin of Health and Disease (DOHAD) hypothesis suggests that early life influences appear as the roots for placing the offspring at a high risk of perinatal mortality. Methylmercury (MeHg) is ubiquitous and persistent environmental pollutant and food contaminant. It’s neurotoxic, especially for the developing nervous system. Contrasting studies on the toxic effects of methymercury (MeHg) during developmental stages of Wistar rats, lead us to investigate the neurofunctional effects caused by its gestational exposure, devoid of any overt sign of toxicity and / or gross malformation. The present neurofunctional/behavioral effects in the offspring on postnatal day (PND) (1-28) were investigated following maternal exposure to methylmercury (0.5, 1.0 and 1.5 mg.kg/day) by oral gavages from gestation day (GD) 15 to till parturition. Slowness of surface righting reflex and pivoting was gender specific with significantly observed in male offspring only. The offspring’s motor ability was investigated using rota rod shows dose dependent significant reduction in latency to fall (sec.) or spent shorter time on rotating rod (10 RPM; cut-off time: 60s) in male offspring. There were significant reductions in forelimb hanging time, significant increases in hindlimb foot splay in female offspring and reductions in forelimb hanging time with MeHg treatment groups was observed. Significantly increases in CNS activity and excitability by measuring numbers of rear in either sex with high dose MeHg treatment group. These results, combined with those of our earlier study, suggest that gestational exposure would enhance the MeHg-induced maternal and embryo/fetal toxicity, confirmed the high- teratogenic potential along with postnatal neurofunctional/behavioral measurements revealed gender and dose specific impairment of neurofunctional/behavioral performance in offspring of mothers suggest to pay increased attention to MeHg concerning its exogenous use during pregnancy.

Dr. Kavita R. Patel, Dr. Rakesh K. Agrawal. "Neurotoxicological Outcomes of Gestational Methylmercury Exposure in Rodents." Computer Engineering, vol. 15, no. 5, pp. 11–21, 2026.

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Proton pump inhibitors [PPI] are acid activated pro drugs which convert in to sulfenic acid and then in to tetracycline sulfenamide in the acidic pH of parietal cell canaliculi. They block H+K+ATPase proton pumps and reduce gastric acid secretion. They are used to treat acid peptic disorders and NSAID induced gastric mucosal injury. Activity of PPI against Helicobactor pylori [H.pylori] is proved undisputably. Lansoprazole is the most effective PPI against H.pylori due to its unique chemical structure.PPI inhibit urease activity of H. pylori. They affect respiration and energy metabolism of these organisms as result of decreased ATP synthesis. Structural similarity of benzimidazole PPI with imidazole like metronidazole and tinidazole may contribute for their antibacterial property. Omeprazole and lansoprazole have been found to have anti fungal activity by inhibition of fungal H+K+ATPase-vacuolar ATPase which are essential for fungal survival and to carry out essential physiological functions, the inhibition of which leads to fungicidal action. Recently anti tubercular action of lansoprazole was highlighted which is attributed to its intra mycobacterial sulfoxide reduction to lansoprazole sulfide. This acts on mycobacterial cytochrome bc1 complex and inhibits ATP synthesis and compromises energy metabolism threatening its survival. Cytochrome bc1 of plasmodium also forms a drug target for lansoprazole. Thus, lansoprazole can emerge as a potential drug to treat MDR tuberculosis and malaria. Antiviral action of lansoprazole was noted against rhinovirus. Gram positive and negative organisms other than H.pylori were found to be inhibited by omeprazole in vitro. But this is not supported by in vivo studies.

Dr. Rohan K. Patel, Dr. Smita J. Mehta, Dr. Aaradhya S. Sheth, Dr. Tushar R. Desai. "Antimicrobial Properties of Proton Pump Inhibitors: A Comprehensive Review." Computer Engineering, vol. 15, no. 5, pp. 22–26, 2026.

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Background: Malaria is one of the most common major health problems responsible for the death of millions of children, pregnant women and adults. Antimalarial drug resistance has emerged as one of the greatest challenges facing malaria control today. Plant resources that either treat or prevent parasite invasion desirable in developing countries are potential targets for research and development of alternative malaria drugs. Objective: This study investigated the suppressive and prophylactic potentials of extracts and some fractions of Adansonia digitata stem bark in Plasmodium berghei infected mice. Methodology: The albino mice were administered with two different doses (200mg/kg body weight and 400mg/kg body weight) of aqueous extract (AQ), methanolic extract (ME), chloroform fraction (CF) and ethylacetate fraction (EF) of Adansonia digitata stem bark for five consecutive days. 5mg/kg body weight dose per day of artemether-lumefantrine and 5mg/kg body weight dose per day of chloroquine was used as positive control while the negative control mice received only the vehicle (5% v/v tween 80). In the prophylactic groups, the mice were pretreated daily for five days before they were challenged with inoculums of 1 x 107 chloroquine-sensitive P. berghei infected erythrocyte intraperitoneally. Results: The results showed a dose dependent chemosupression in the fractions and the extract treated groups. The 400mg/kg body weight was more effective with respect to the parasite clearance than the 200mg/kg body weight in all the groups. Both the 200mg/kg and 400mg/kg body weight dose of ethylacetate fraction (EF) exhibited the highest chemosupression. The chemosupression caused by Artemether-lumefantrine (AL) and Chloroquine (CQ) treated groups were significantly (P< 0.05) higher than the fractions and extract treated groups. The percentage parasitemia also decreased in this manner. There was a mutual delay in parasitemia with EF and ME. The packed cell volume (PCV) increased significantly (P< 0.05) in the AL and CQ, and 400mg/kg body weight dose EF and ME respectively and increased for the other fraction and extract used at 400mg/kg body weight dose compared with the control. Conclusion: This study showed that EF of Adansonia digitata stem bark has potent antimalarial property which could be of future importance in malaria management.

Oluwafemi Omotayo Afolayan, Olayinka Olusegun Adetunji, Ayobami Olusegun Adeyemi. "Evaluation of Adansonia digitata Stem Bark Extract and Derived Fractions for In Vivo Antimalarial Activity." Computer Engineering, vol. 15, no. 5, pp. 27–33, 2026.

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Psychosis is a complex mental illness, characterised by positive, negative and cognitive symptoms. NMDA receptor antagonists have been established to induce behavioural as well as biochemical changes in rodents similar to psychotic patients. The aim of the present study was to investigate the effective dose and treatment period of ketamine to induce some behavioural changes. The results suggest that acute treatment of ketamine (50 and 100 mg/kg, i.p.) induced hyperlocomotor activity and reduced step down latency time in passive avoidance test, whereas in effective in forced swim test. Further, with the chronic administration of ketamine (50 and 100 mg/kg, i.p.) effective to produced hyperlocomotor activity, reduced the step down latency time in passive avoidance test and enhanced the immobility duration in forced swim test. Moreover, these behavioural changes persisted for 7 days after the treatment period. Thus, our findings suggest that the chronic administration of Ketamine (50 and 100 mg/kg, i.p.) potential to produce behavioural changes, would serve as an effective tool to screen antipsychotic drugs.

Dr. Rohan K. Patel, Dr. Aishwarya R. Sengupta, Dr. Leela V. Rao, Dr. Vikram M. Mehta. "Standardizing Ketamine-Induced Psychosis in Mice: A Comparative Study of Acute and Chronic Administration." Computer Engineering, vol. 15, no. 5, pp. 34–39, 2026.

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The notochord is a midline structure common to all chordate animals; it provides mechanical and signaling cues for the developing embryo. In vertebrates, the notochord plays key functions during embryogenesis, being a source of developmental signals that pattern the surrounding tissues. It is composed of a core of vacuolated cells surrounded by an epithelial-like sheath of cells that secrete a thick peri-notochordal basement membrane made of different extracellular matrix (ECM) proteins. The correct deposition and organization of the ECM is essential for proper notochord morphogenesis and function. Work carried out in the past two decades has allowed researchers to dissect the contribution of different ECM components to this embryonic tissue. Here, we will provide an overview of these genetic and mechanistic studies. In particular, we highlight the specific functions of distinct matrix molecules in regulating notochord development and notochordderived signals. Moreover, we also discuss the involvement of ECM synthesis and its remodeling in the pathogenesis of chordoma, a malignant bone cancer that originates from remnants of notochord remaining after embryogenesis.

Alessandra Bianchi, Lorenzo Mariani, and. "Mechanisms of Notochord Development and Pathophysiology: Elucidating the Role of the Extracellular Matrix." Computer Engineering, vol. 15, no. 5, pp. 40–49, 2026.

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Abstract not available.

Dr. Giuseppina Marsico. "Navigating the Transition: The Role of the Educational Self in Cultural Psychology.." Computer Engineering, vol. 15, no. 5, pp. 50–58, 2026.

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