Sidaguri (S. rhombifolia L) is one of the most important species of medicinal part in Indonesia as anti-inflammation. To clarify this, we investigated the anti-inflammatory effect of the root of S. rhombifolia on rat periapical lesion model. The incisivus teeth were drilled to expose the dental pulp to the oral cavity and apical lesions were induced with LPS isolated from Porphyromonas gingivalis. Pour plate method was used to determine the bacterial CFU of gingival crevicular fluid (GCF) and C-reactive protein (CRP) serum was examined by enzyme-linked immunosorbent assay. The results showed that the root of S. rhombifolia could not reduce the total bacteria of GCF; however, it could reduce the level of CRP compared to negative control (p<0.05). In conclusion, S. rhombifolia has anti-inflammatory potency on rat periapical lesion.

Dr. Ariana W. Wijaya, Dr. Raden A. P. Kusuma, Dr. Irfan H. Pohan. "Investigating the Anti-Inflammatory Properties of Sida rhombifolia L. in a Rat Periapical Lesion Model." Computer Engineering, vol. 15, no. 3, pp. 1–4, 2026.

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Objective: Myristica fragrans Houtt commonly used as traditional medicine for alleviating of various disorders. The purpose of our study was to map out the in vitro antioxidant property and in vivo anti-hyperglycemic and analgesic effect of the methanolic extract of Myristica fragrans Houtt. (Seed and mace) (Myristicaceae) on Swiss albino mice. Methods: The processed powder of Myristica fragrans Houtt (seed and mace) were subjected to methanolic extraction by soxhlet filtration methods, and the desiccated extract was used for screening of antioxidant by DPPH free radical scavenging assessment as well as total phenolic content by using folin-ciocalteu reagent.Anti-hyperglycemic effect and analgesic action tested through alloxan induced antidiabetics test and acetic acid-tempted writhing test on mice. Results: In DPPH free radical scavenging assessment, free radicals neutralization expressed as % of inhibition 49.69±0.06% also by IC50 values as 68.43 µg/ml surmise middle level of antioxidant property. The total phenolic content expressed as 186.25 mg/g equivalent of gallic acid indicates, active phenolic content. Oral administration of 200 and 400 mg/kg of extract dose and reference drug vildagliptin (50 mg/kg) for the duration of the 4-day study period, and initiated % of inhibition the blood glucose level measured as 22.48%, 44.78% and 62.02% regard as the significant anti-hyperglycemic properties. The analgesic activity was investigated by using the acetic acid-induced writhing test in mice, at the dose of 200 mg/kg body and 400mg/kg weight, and resulting 50.4% and 68.10% correspondingly, which was considerably significant with a standard drug. Conclusion: The present study suggests that methanolic extract of seed and mace of Myristica fragrans Houtt can manage moderate oxidative stress as well as perform the painkilling action. Besides, prolong medication may enhance the new dimension of anti-hyperglycemic activity.

Amira Khalida Fatima and Ahsan Habib. "Phytochemical and Pharmacological Evaluation of Myristica fragrans Houtt (Myristicaceae): A Comprehensive Review." Computer Engineering, vol. 15, no. 3, pp. 5–12, 2026.

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AimThis study examined the outputs of research papers in diabetes from 31 European countries between 2002 and 2013, and their funding.Methods Diabetes research papers in the Web of Science were identified by means of a filter based on journals and title words. For 2009–2013 papers, the funders were coded to show their sector and nationality.Results Europe published 40 547 diabetes papers in the 12 years between 2002 and 2013. Denmark, Sweden and Finland published the most relative to their wealth, but the UK published the most absolutely despite an apparently low burden (as measured by disability-adjusted life years). The largest source of funding was government (30%), followed by the non-profit sector (18%) and industry (13%). The European Commission supported 2.7% of papers, but more in Latvia (33%) and Estonia (16%). Based on an estimated cost per paper of €260 000, the annual research expenditure in Europe was approximately €986 million in 2013.ConclusionsThe European diabetes burden in disability-adjusted life years increased by one third between 2002 and 2012, but its output of research papers has decreased from 44% to 36% of the world total. This decrease needs to be reviewed in the context of European non-communicable disease research policy.

1 A. K. Patel, E. J. Martin, 2 C. R. Fabbri, 3 L. M. Bianchi, 4 P. E. Vickers, 4 M. C. Di. "Examining Funding Patterns in European Diabetes Research from 2002 to 2013." Computer Engineering, vol. 15, no. 3, pp. 13–18, 2026.

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Although potentiated sulfonamides as effective and broad-spectrum antimicrobials are frequently used in broiler farms, prescribing these agents may be associated with concerns about their toxicity especially regarding the fact that their toxic and therapeutic doses are usually close. This study evaluates toxicity of sulfadimethoxine-trimethoprim due to administration of higher doses or for longer period than what is recommended in broilers with regard to clinical signs, gross pathological examination, histopathological changes of liver and kidney as well as selected serum parameters. We found that sulfadimethoxine-trimethoprim use is relatively safe in broilers although high doses may be more damaging than long term use especially with regard to kidney function. The outcome of this study is useful in reducing the concerns related to severe toxic effects in chickens when unintentional over administration has been occurred but does not affect the need for use of recommended dosages as indicated in drug label.

1Fatima K. Alizada, 2Ali R. Saeedi, 1Mohammad R. Ghasemi, 3Nader M. Seyedfatemi, 4Amir. "Long-Term Toxicity Evaluation of Sulfadimethoxine-Trimethoprim in Broilers: A Pharmacological and Toxicological Analysis." Computer Engineering, vol. 15, no. 3, pp. 19–22, 2026.

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: The interaction between the body system and a microgravity environment influences the biomechanical behaviors allowing the reorganization of sensorimotor relations through “unique” stimulation of the functional hierarchies of the central nervous system, thus changing the motor gesture as a whole. The physical characteristics of the aquatic environment can be exploited by the rehabilitative operator to achieve specific muscle, neurological and sensory recovery with different modality and times compared to the techniques used in a dry environment, stimulating the re- acquisition of neuromotor-sensory skills impaired or even lost. The purpose of the study is to evaluate the effectiveness of a rehabilitation protocol in the thermal aquatic environment, on postural parameters, gait, balance, and autonomy on the disabled patient. 50 subjects (mean age 48.5 years) were evaluated and treated because of the suffering of neuromotor cognitive and/or mental disabilities. Subjects underwent two evaluations, before and after a rehabilitation protocol in aquatic environment, consisting of 20 therapy sessions in thermal water, made of a physiatric specialistic examination, administration of FIM and Tinetti SCALE and Computerized Postural assessment without markers (Sa.BB Imaging), in order to assess the effects of the protocol on the health status of the patient, evaluating the ADL, balance and postural parameters and if these three data show a correlation in clinical practice. Considering the scores of the FIM scale, neurological patients went from a score of 84,323 to 97,29 after 20 sessions of treatment (p=0.0487). Patients with mental disabilities increased from a score of 76,895 to 94,63 (p = 0.0383). In all patients the FIM scale score increased from 82,692 to 95,75 (p = 0.0107). Gait and balance, evaluated through the Tinetti scale, improved from 20,105 to 24,474 (p=0.04) for patients with mental disabilities and from 11,774 to 13,742 (p = 0.4688) for patients with neuromotor disabilities. In all patients the Tinetti score rose from 13,385 to 17,885 (p = 0.4688). These data were validated by the improvements achieved at the postural level, particularly in the values concerning the anteposition of the head, important for the distribution of the load in the polygon of support; also supported by the reduction of the lateral side oscillations of the pelvis. We can conclude that the technique used resulted in a great increase of postural and functional parameters of the subjects of the study.

Dr. Jaan Valsiner. "The Role of Aquatic Rehabilitation in Neurological and Cognitive Recovery." Computer Engineering, vol. 15, no. 3, pp. 23–29, 2026.

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Action and speech may take different forms, being expressed, for example, gently or rudely. These aspects of social communication, named vitality forms, have been little studied in neuroscience. In the present functional magnetic resonance imaging study, we investigated the role of insula in processing action and speech vitality forms. In speech runs, participants were asked to listen or imaging themselves to pronounce action verbs gently or rudely. In action runs, they were asked to observe or imaging themselves to perform actions gently or rudely. The results showed that, relative to controls, there was an activation of the dorso-central insula in both tasks of speech and action runs. The insula sector specific for action vitality form was located slightly more dorsally than that of speech with a large overlap of their activations. The psycho-physiological interaction analysis showed that the insular sector involved in action vitality forms processing is connected with the left hemisphere areas controlling arm actions, whereas the sector involved in speech vitality forms processing is linked with right hemisphere areas related to speech prosody. We conclude that the central part of the insula is a key region for vitality forms processing regardless of the modality by which they are conveyed or expressed.

Alessandro Bianchi, Elena Rossi, Lorenzo Ferrari, Francesca Zampieri, Andrea Bellazzi. "Mirroring the Social Aspects of Speech and Actions: An Exploration of the Insula's Role." Computer Engineering, vol. 15, no. 3, pp. 30–38, 2026.

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Cancer stem cells (CSC) form a specific population within tumor can be targeted. We have recently developed an NCAMthe tumor that has been shown to have self-renewal and targeted nanosized conjugate of paclitaxel bound to a biodedifferentiation properties, increased ability to migrate and gradable polyglutamic acid polymer. In this work, we examform metastases, and increased resistance to chemotherapy. ined the ability of the conjugate to inhibit Wilms tumor Consequently, even a small number of cells remaining after by targeting the NCAM- expressing CSCs. Results show that therapy can repopulate the tumor and cause recurrence of the the conjugate selectively depleted the CSC population of the disease. CSCs in Wilms tumor, a pediatric renal cancer, were tumors and effectively inhibited tumor growth without causpreviously shown to be characterized by neural cell adhesion ing toxicity. We propose that the NCAM-targeted conjugate molecule (NCAM) expression. Therefore, NCAM provides a could be an effective therapeutic for Wilms tumor. Mol Cancer specific biomarker through which the CSC population in this Ther; 16(11); 2462–72. 2017 AACR.

Dr. Maya Kaminer, Dr. Yael Aharoni, Dr. Rachel Alon, Dr. David Cohen, Dr. Neta. "Evaluating the Interplay of Molecular Mechanisms in Tumor Microenvironment." Computer Engineering, vol. 15, no. 3, pp. 39–50, 2026.

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: The lipid fraction of Asiago Protected Designation of Origin (PDO) cheese was analyzed to identify specific biomarkers of its main production systems through a canonical discriminant analysis. The three main production systems of the cheese were considered. Two were located in the upland (UL): pasture-based (P-UL) vs hay-based total mixed rations (H-UL). The third was located in the lowland (LL) and processed milk from cows fed maize silage-based rations (maize silage lowland: MS-LL). The discriminant analysis selected nine fatty acids and vitamin A as lipid biomarkers useful to separate the three production systems. High contents of conjugated linoleic acids, anteiso-C15:0, and vitamin A were discriminant factors for P-UL cheese. The separation between H-UL and MS-LL cheese was less marked with the former having the higher content of conjugated linoleic acids and some polyunsaturated n-6 fatty acids and with the latter being identified by cyclopropane fatty acid and C9:0.

Alessandro Bianchi, Elena Russo. "Discriminating Lipid Biomarkers in Asiago PDO Cheese Production Systems." Computer Engineering, vol. 15, no. 3, pp. 51–57, 2026.

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